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Publications

Keratinocyte Pannexin-1 is essential for nerve trauma-induced mechanical hypersensitivity.

Christina M. Mecca Olena Isaeva, Alexander R. Mikesell, Anvitha Sriram, Bradey A. Stuart, Bhavya Dharanikota, Cheryl L. Stucky. BioRxiv. October 2025.

DRG Stimulation of Injured Sensory Neurons in Rats Rapidly Eliminates their Spontaneous Activity and Relieves Spontaneous Pain.

Dongman Chao, PhD; Christina M. Mecca, BS Guoliang Yu, PhD; Ian Segel, BS; Michael S. Gold, PhD; Quinn H. Hogan, MD; Bin Pan, Ph.D. PAIN. April 2021.

Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice

Katelyn Sadler, Francie Moehring, Stephanie Shiers, Lauren J. Laskowski, Alexander R. Mikesell, Zakary R. Plautz, Christina M. Mecca, Gregory Dussor, Theodore J. Price, John McCorvey, Cheryl Stucky. Science Translational Medicine. May 2021.

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Repetitive Anesthesia-free Mild Traumatic Brain Injury in Rats induces Cognitive Impairment, Increased mPFC Activity due to Neuronal Disinhibition.

Yin Feng*, Keguo Li*, Elisabeth Roth*, Dongman Chao, Christina M. Mecca, Quinn H. Hogan, Christopher Pawela, Wai-Meng Kwok, Amadou KS. Camara, Bin Pan. Experimental Neurology. Aug 2021

Abstracts

Keratinocytes are essential for mechanical and cold hypersensitivity after peripheral nerve injury.

Christina M. Mecca, Elena Isaeva, Alexander R. Mikesell, Anvitha Sriram, Bradey A. Stuart, Bhavya Dharanikota, Cheryl L. Stucky. 2025 Wisconsin Pain Research Day at Medical College of Wisconsin in Milwaukee, WI, 2025​

Keratinocytes Contribute Substantially to Traumatic Nerve Injury-Induced Mechanical Hypersensitivity.

Christina M. Mecca, Alexander R. Mikesell, Olena Isaeva, Cheryl L. Stucky. Society for Neuroscience, Presentation No. PSTR401.24. Annual meeting of the Society for Neuroscience in Chicago, IL, 2024

Contributions of keratinocytes to traumatic nerve injury induced mechanical and cold hypersensitivity.

Christina M. Mecca, Alexander R. Mikesell, Olena Isaeva, Cheryl L. Stucky. Society for Neuroscience, Presentation No. PSTR409.16. Annual meeting of the Society for Neuroscience in Washington DC, 2023

Modulation of purinergic signaling in keratinocytes in spared nerve injury model of neuropathic pain.

Elena Isaeva, Christina Mecca, Anthony Menzel, and Cheryl L Stucky. US Association for the Study of Pain, Presentation No. 231. Annual Meeting in Cincinnati, OH, 2022

Keratinocyte PIEZO1 Mediates Touch Sensation and Touch Allodynia.

Alexander Mikesell, Francie Moehring, Katelyn Sadler, Christina Mecca, Cheryl L. Stucky. US Association for the Study of Pain, Presentation No. 119. Annual Meeting in Cincinnati, OH, 2022

TRPC5 is required for mechanical hypersensitivity in persistent inflammatory pain models.

Katlyn Sadler, Francie Moehring, Christina Mecca, Cheryl L. Stucky Society for Neuroscience, Presentation No. 056.08/J20. Annual meeting of the Society for Neuroscience in Chicago, 2019

The behavioral effects of taurine in aggression of female crayfish, Procambarus clarkii.

Christina M. Mecca, Brittany N. Thomas, Robert F. Waldeck. Society for Neuroscience, Presentation No. 503.06/KK23. Annual meeting of the Society for Neuroscience in Washington DC, 2017

The behavioral effects of taurine of male crayfish, Procambarus clarkii.

Brittany N. Thomas, Christina M. Mecca, Robert F. Waldeck. Society for Neuroscience, Presentation No.160.19/UU9. Annual meeting of the Society for Neuroscience in San Diego, 2016 ​​​​

Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Contributes to Depression after Neuropathic Pain.

Christina M. Mecca, Dongman Chao, Guoliang Yu, Ian Segel, Zhiyong Zhang, Christopher Pawela, Cecilia J. Hillard, Quinn H. Hogan, Bin Pan. Journal of Neuroscience. July 2021

Analgesic Dorsal Root Ganglionic Field Stimulation Blocks Conduction of Afferent Impulse Trains Selectively in Nociceptive Sensory Afferents.

Dongman Chao, Zhiyong Zhang, Christina M. Mecca, Quinn Hogan, Bin Pan. PAIN. July 2020.

Elevated Lymphotoxin α (TNFβ) is associated with intervertebral disc degeneration.

Zhu Guo, Chensheng Qiu, Christina Mecca, Yang Zhang, Jiang Bian, Yan Wang, Xiaolin Wu, Tianrui Wang, Weiliang Su, Xianglin Li, Wei Zhang, Bohua Chen, Hongfei Xiang. BMC Musculoskeletal Disorders. January 2021

High-speed imaging of evoked rodent mechanical behaviors yields variable results that are not predictive of inflammatory injury.

Dianise M. Rodríguez García, Aniko Szabo, Tyler B. Waltz, Alexander R. Mikesell, Samuel J. Zorn , Anvitha Sriram , Christina M. Mecca , Ulrich Kemmo Tsafack , Cheryl L. Stucky , Katelyn E. Sadler. PAIN. July 2024.

Sensory neuron PIEZO1 deletion inhibits dynamic light touch sensitivity in uninjured mice, prevents neuropathic light touch hypersensitivity, and drives compensatory changes in dorsal root ganglia.

Vanesa L. Ehlers; Anvitha Sriram; Bradey A. R. Stuart; Christina M. Mecca; Cheryl L. Stucky. PAIN. August 2025.

Keratinocytes Contribute to Traumatic Nerve Injury-Induced Mechanical Hypersensitivity.

Christina M. Mecca, Alexander R. Mikesell, Olena Isaeva, Cheryl L. Stucky. US Association for the Study of Pain, Presentation No. 22. Annual Meeting in Seattle WA, 2024. Received poster award.

Keratinocyte pannexin-1 contributes to mechanical and cold allodynia after spared nerve injury.

Christina M. Mecca, Elena Isaeva, Cheryl L. Stucky.US Association for the Study of Pain, Presentation No. 311. Annual Meeting in Durham, NC, 2023

Contributions of keratinocytes to traumatic nerve injury induced mechanical and cold hypersensitivity.

Christina M. Mecca, Alexander R. Mikesell, Olena Isaeva, Cheryl L. Stucky. Society for Neuroscience, Presentation No. PSTR409.16. Annual meeting of the Society for Neuroscience in Washington DC, 2023

Transient Receptor Potential Vanilloid 4 Mediates Hypersensitivity in Chronic Sickle Cell Disease Pain.

Vanessa Ehlers, Katelyn Sadler, Anthony D. Menzel, Christina M. Mecca, Cheryl L. Stucky. US Association for the Study of Pain, Presentation No. C2. Annual Meeting in Cincinnati, OH, 2022

Dynamic and Divergent Changes of Endocannabinoid Signaling in the Peripheral and Central Nervous System after Neuropathic Pain.

Christina Mecca, Guoliang Yu, Quinn Hogan, Bin Pan. International Cannabinoid Research Society, Submission Passcode: 203X-A7P5A6G3F5. The 30th Annual International Cannabinoid Research Society Symposium on the Cannabinoids in Galway Ireland, 2020. Canceled Due to COVID-19 Pandemic.

Contributions of taurine and baclofen to subordinate female crayfish, Procambarus clarkii.

Christina M. Mecca, Sarah A. Liskowicz, Robert F. Waldeck Society for Neuroscience, Presentation No. 067.16/O42. Annual meeting of the Society for Neuroscience in Chicago, 2019 

Contributions of Taurine to Aggressive and Escape Behaviors in the Female Crayfish, Procambarus clarkii.

Christina M. Mecca, Robert F. Waldeck. National Council on Undergraduate Research, Presentation No. 44B. Annual Meeting of National Council on Undergraduate Research in Kennesaw, GA, 2019

Contributions of taurine to the loser effect and the escape response in the female crayfish, Procambarus clarkii.

Christina M. Mecca, Robert F. Waldeck Society for Neuroscience, Presentation No. 152.23/QQ21. Annual meeting of the Society for Neuroscience in San Diego, 2018

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Contact
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cmeccaphd@outlook.com

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Milwaukee, WI

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